Nazeem Fahamiya1, Mohd.
Aslam1, Kalim Javid2, Aisha Siddiqui1, Mohamed Shiffa3, Shazad Yaqub1, MuneedU.
Rehman4
1Department of Ilmul
Advia (Pharmacology), Faculty of Medicine (Unani), Jamia Hamdard, New Delhi
-110062, India
2Department of
Chemistry, Faculty of Science, Jamia Hamdard, New Delhi - 110062, India
3Department of Moalijat
(Medicine), Faculty of Medicine (Unani), Jamia Hamdard, New Delhi - 110062,
India
4Department of
Toxicology, Faculty of Science, Jamia Hamdard, New Delhi - 110062, India
ABSTRACT
The seed of Cucumis melo
Linn. is having diuretic, lithotriptic, laxative, demulcent and cooling
properties. The present investigation was carried out to evaluate the
nephroprotective activity of methanolic extract of Cucumis melo (ME-CM) seed
kernel in gentamicin-induced nephrotoxicity. The ME-CM was administrated orally
(190 mg/kg/d) for 8 days. Gentamicin was administrated at the dose of 100 mg/kg
daily in neck region subcutaneously from 4 th to 8 th day. Gentamicin (alone)
treated group showed increased levels of blood urea nitrogen and serum
creatinine, which were significantly retrieved in group pretreated with ME-CM.
The antioxidant study revealed that the level of superoxide dismutase (SOD),
catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were
increased with decrease in malondialdehyde (MDA) content in ME-CM pretreated
group when compared with gentamicin alone treated group. The histopathological
analysis also showed the protective nature of ME-CM in gentamicin-induced renal
damage. In conclusion, the histopathological and biochemical parameters
confirmed that the ME-CM protect against gentamicin induced renal damage
probably through its antioxidant activity.
Available at:
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